SIT. READ. GOOD DAWG.
The goal of this study was to determine, through oral ingestion, (1) the short-term safety and (2) pain-killing efficiency of CBD based oil administered to dogs with osteoarthritis and additionally to (3) gain insight on dosing, benefits and adverse effects, as compared to a placebo.
Osteoarthritis (OA) is a degenerative joint disease which is the progressive & permanent deterioration of cartilage surrounding the body’s joints.
Prior to diving into the study, their hypothesis was “that appropriate dosing of CBD-rich oil would safely diminish perceived pain and increase activity in dogs with OA.”
Allow us to paint a picture, highlighting important details about how this study took place:
- A commercial analytical laboratory (MCR Laboratories, Framingham, MA) analyzed five different production runs of the CBD enriched oil .
- Analysis showed less than a 9% difference across batches for each of the detected cannabinoids listed below.
- ~10 mg/mL of CBD as an equal mix of CBD and carboxylic acid of CBD (CBDa), 0.24 mg/mL tetrahydrocannabinol (THC), 0.27 mg/mL cannabichromene (CBC), and 0.11 mg/mL cannabigerol (CBG); all other cannabinoids were less than 0.01 mg/mL.
- The Cornell University Institutional Animal Care and Use Committee (IACUC) approved the study following the guidelines for animal use according to the IACUC, before the study took place.
- “Client owned dogs were enrolled after informed consent in accordance with the Declaration of Helsinki.”
- Randomized Placebo Controls
- Veterinarian and Owner Blinded Crossover Study
- “CBD Enriched Oil”
- Proprietary Strain of Industrial Hemp
- Ethanol & Heat Extraction
- Final Extraction Added to an Olive Oil Base
- 4 Beagles
- 3.5 – 7 years old
- Male; castrated
- 10.7–11.9 kg
- Dogs were given a regime of either CBD Oil or Placebo Oil.
- Dogs got 2 treatments a day; every 12 hours.
- Analysis was taken at (2) different doses (2mg/kg) & (8mg/kg)
- The dogs were fed 2 hours after dosing.
- 4 week treatment & 2 week washout period
- A washout period is defined as the time between treatment periods. Instead of immediately stopping and then starting the new treatment, there will be a period of time where the treatment from the first period where the drug is washed out of the patient’s system.
STEPS OF EVALUATION
- The dog’s owner and the vet individually completed 3 questionnaires: before beginning each treatment, at 2 weeks and again at 4 weeks.
- Examination & evaluation was performed at 0, 4, 8, and 24 hours after dosing.
- Physical examination consisted of free running/walking and navigation around standard traffic cones (weaving).
- Subjective Evaluation consisted of attitude, behavior, proprioception (perception or awareness of the position and movement of the body), and gait (manner of walking).
- Five milliliters of blood was collected at times: 0, 0.5, 1, 2, 4, 8, 12, and 24 hours after oil administration.
- Blood samples were obtained via jugular venipuncture and transferred to a coagulation tube for 20 min.
- Samples were centrifuged with a clinical centrifuge at 3,600 × g for 10 min.
- Serum was removed and stored at −80°C until analysis using liquid chromatography-mass spectrometry (LC-MS) at Colorado State University Core Mass Spectrometry facility.
- Hematology, serum (oil) chemistry and physical examinations were performed at each visit.
- Hematology is the branch of medicine concerned with the study of the cause, prognosis, treatment, and prevention of diseases related to blood.
- Analyzation at given points was based upon comparing the change from baseline.
- A variable with a p ≤ 0.05 is defined as significant.
This pharmacokinetic and clinical study suggests that 2 mg/kg of CBD twice daily can help increase comfort and activity in dogs with OA.
- Pharmacokinetics revealed:
- An elimination half-life of 4.2 hours at both doses.
- No observable side effects.
- Canine brief pain inventory and Hudson activity scores showed a significant decrease in pain and increase in activity (p < 0.01) with CBD oil.
- Veterinary Assessment
- Showed decreased pain during CBD treatment (p < 0.02).
- Side Effects
- No side effects were reported by owners.
- Serum chemistry showed an increase in alkaline phosphatase during CBD treatment
(p < 0.01).
THINK ABOUT IT
We’re not going to draw any further conclusions for you, but hope you’ll take a moment to consider how valuable this information is in validating use of CBD with dogs.
Looking for a CBD Tincture? Look no further!
Chemdawg’s Due Diligence
Every unique body is differently affected by the various ingredients in our nutritional supplements, so we can not offer any guarantees with our products. It’s important to test one product at a time, consistently in order to properly gauge effectiveness. Try not to judge effectiveness after just one use; products are intended to be used consistently. If a negative reaction occurs, discontinue immediately and speak with your vet.
If you have any questions or curiosities, please make an effort to see the original published document. There was information available that we did not include in our summary.